In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Sign in to follow this  

Case Number : Case 1877 - 08 August - Dr Diwan Posted By:

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)

38-year-old hospitalized patient status post chemotherapy, with lung infiltrates, neutropenia and numerous erythematous papular nodules on trunk and extremities. This biopsy is from the left arm. (Images courtesy of Dr. Heather Barker.)

Sign in to follow this  

User Feedback


Dr. Mona Abdel Halim

Posted · Report

Hematolymphoid infiltrates for complete IHC. Can not predict anything from morphology actually. 

Share this comment


Link to comment
Share on other sites
vincenzo polizzi

Posted · Report

Lymphomatoid granulomatosis (for cpc of course!!!)

The infiltrate seems angiocentric, and some cells are larger (EBV+ B-cells) then others (reactive T-cells), but it's a lot difficult with these photos...

Share this comment


Link to comment
Share on other sites
Dr. Hafeez Diwan

Posted · Report

Leukemia cutis.  Patient has AML.  MPO is positive.

Share this comment


Link to comment
Share on other sites
Saman Fatah

Posted · Report

This dermal infiltrate is predominantly perivascular mononuclear cellular infiltrate with stands of single cells between the collagen bundles. There is subtle pallor of papillary dermis but no convincing oedema. MPO will stain the premature granulocytes and I wounder how this infiltrate is different from "Histiocytoid" Sweet's Syndrome? AML is one of well known Haematological malignancies associates with SS (besides MDS and others). The clinical context and sometimes only a period of observation can clarify this distinction. 

Iam grateful if any Dermatopathologist colleague can educate me if such distinction is possible on histology/IHC?

Classical SS is diffuse dense band like but predominant perivascular distribution can be seen (probably depending on the age and morphology of the lesion biopsied).

Thanks

 

Share this comment


Link to comment
Share on other sites
Anil Patki

Posted · Report

Another feature seen in this slide is hyalinization of collagen. Is this seen only in this malignancy? Pubmed search for hyalinization of collagen by malignant cells shows no results

Share this comment


Link to comment
Share on other sites


Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now